The role of mitotic cell-substrate adhesion re-modeling in animal cell division
Published in Developmental cell, January 2018
Publisher: Elsevier
The manuscript by Dix et al. (2018) published in Developmental Cell explores the significance of mitotic cell-substrate adhesions during RPE1 cell division. The study reveals that integrin-based adhesions persist during mitosis, forming a stable pool of active b1-integrin that aids in daughter cell re-spreading and division, even in the absence of a visible actomyosin ring. The findings suggest that these adhesions are crucial for RPE1 cell division, particularly when the actomyosin cortex is compromised. Another manuscript by Labernadie et al. (2017) investigates a mechanically active heterotypic E-cadherin/N-cadherin adhesion's role in enabling fibroblasts to drive cancer cell invasion. The study found that this adhesion forms during mitosis and disassembles during cytokinesis, playing a vital role in cancer cell invasion through mechanical forces. Both studies highlight the importance of cell-substrate adhesions in various cellular processes, including cell division and cancer progression.