Research Team

Yue Yuan

Yue Yuan

PhD Student

Started in: September 2017

Ended in: November 2021

Funding: Alumni

Yue Yuan is also known as Julie. Julie was a 5-year PhD Student in our research group. Was supervised by Ricardo Henriques, Mark Marsh, Dylan Owen and Romain Laine. Worked on 2 publications. Collaborated with 2 labs.

Host receptor engagements is one of the first steps during HIV entry. There is still a lack of explicit knowledge on the precise stoichiometry of the virus Env-receptor interaction or of how flexible this might be for a successful fusion event, especially from the perspective of predominant viral target cells (CD4+ T cells). A better understanding of PM receptor distributions, and how this is modulated by the virus, is still required. I am aiming at characterising this dynamic process using Super-Resolution Microscopy on a single-cell level. We have successfully validated a pipeline to quantitatively analyse the topology of membrane receptors, CD4 and CCR5. Our next step is to investigate further what receptor topology makes a fusion-efficient by monitoring viral entry in living CD4+ T cells.


Mark Marsh

Mark Marsh

London, UK

Joint: 4 2

Pedro Matos Pereira

Pedro Matos Pereira

Oeiras, Portugal

Joint: 19 3

Publications with our group

Single-Molecule Super-Resolution Imaging of T-Cell Plasma Membrane CD4 Redistribution upon HIV-1 Binding
Yue Yuan, Caron A. Jacobs, Isabel Llorente Garcia, Pedro M. Pereira, Scott P. Lawrence, Romain F. Laine, Mark Marsh, Ricardo Henriques
Paper published in Viruses, January 2021
Technologies: CARE
Funded by: ERC
DOI: 10.3390/v13010142
Between life and death - strategies to reduce phototoxicity in super-resolution microscopy
Kalina L Tosheva, Yue Yuan, Pedro Matos Pereira, Siân Culley, Ricardo Henriques
Review published in Journal of Physics D - Applied Physics, January 2020
Technologies: CARE, NanoJ, NanoJ-Fluidics and NanoJ-SRRF
Funded by: BBSRC and Wellcome Trust
DOI: 10.1088/1361-6463/ab6b95