Research Team
Romain was a 3-year Postdoc in our research group. Worked on 13 publications. Contributed to 8 technologies. Raised 3 grants. Collaborated with 13 labs. Mentored 1 Masters Student, 1 Internship Student, 2 PhD Students.
Overview: I am interested in developing and applying advanced microscopy techniques to decipher functional and structural organisation of life at multiple scales. For this, I develop analytical and optical tools. You can find me on Twitter (@LaineBioImaging), in the optics lab tinkering with microscopes or on my computer developing image analyses.
Background and how I ended up coming to the LMCB? French but I have been living in the UK for long enough to have forgotten how real buttery pastries taste like. I did my PhD at Imperial College in biophotonics (throwing lasers and microscopes at cells and molecules !), then moved to Cambridge for PostDoc to develop super-resolution microscopy (throwing more lasers and more microscopes at cells and molecules !). I now joined Ricardo’s lab and I want to exploit my microscopy skills to study more complex biological systems with my microscopy skills (throwing some cells at my microscope!).
Reason(s) that made me get into science? The idea (and ideal) of discovery!
Where do I see myself in 5 years? Head of my own lab, working on fast 3D microscopy to understand viral replication at cellular and sub-cellular levels.
Any hobbies? Capoeira and cooking ! (a well-balanced system of input and output of calories).
In the news
- 2023-11-27: News outlet Photonics.com highlights Laine et al. Nature Methods 2023
- 2023-11-20: News outlet The Science Times highlights Laine et al. Nature Methods 2023
- 2023-11-16: News outlet Optics.org highlights Laine et al. Nature Methods 2023
- 2023-11-14: Blog Springer Nature Protocols and Methods Community highlights Laine et al. Nature Methods 2023
- 2023-11-14: News outlet Phys.org highlights Laine et al. Nature Methods 2023
- 2022-11-15: News outlet Technology Times highlights Almada et al. Nature Communications 2019
- 2022-06-18: News outlet MSN highlights Almada et al. Nature Communications 2019
- 2022-06-18: News outlet DNYUZ highlights Almada et al. Nature Communications 2019
- 2022-06-18: News outlet Express Informer highlights Almada et al. Nature Communications 2019
- 2021-11-03: Editorial in Nature Methods highlights Chamier et al. Nature Communications 2021
- 2021-05-07: News outlet Expresso highlights Chamier et al. Nature Communications 2021
- 2021-04-26: News outlet AZO Life Sciences highlights Chamier et al. Nature Communications 2021
- 2021-04-26: News outlet Drug Target Review highlights Chamier et al. Nature Communications 2021
- 2021-04-24: News outlet Nanotechnology Now highlights Chamier et al. Nature Communications 2021
- 2021-04-24: News outlet The Medical News highlights Chamier et al. Nature Communications 2021
- 2021-04-16: Blog Microbiome Digest - Bik's Picks highlights Chamier et al. Nature Communications 2021
- 2020-04-21: Editorial in Nature highlights Chamier et al. Nature Communications 2021
- 2018-07-17: News outlet The Scientist highlights the lab's research
Supervisees
Collaborations
Christophe Leterrier
Aix Marseille Université, CNRS, INP
Marseille, France
Joint:
9
Guillaume Jacquemet
Abo Akademi University
Turku, Finland
Joint:
13
Loïc Royer
Chan Zuckerberg Biohub
San Francisco, USA
Joint:
2
Séamus Holden
Warwick University
Warwick, UK
Joint:
5
Technologies
Publications with our group (see more on Google Scholar)
|
High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation Romain F. Laine, Hannah S. Heil, Simao Coelho, Jonathon Nixon-Abell, Angélique Jimenez, Theresa Wiesner, Damián Martínez, Tommaso Galgani, Louise Régnier, Aki Stubb, Gautier Follain, Samantha Webster, Jesse Goyette, Aurelien Dauphin, Audrey Salles, Siân Culley, Guillaume Jacquemet, Bassam Hajj, Christophe Leterrier, Ricardo Henriques Paper published in Nature Methods, November 2023 Technologies: CARE, NanoJ, NanoJ-eSRRF, NanoJ-SQUIRREL, NanoJ-SRRF, NanoPyx and Nuclear-Pores as references Funded by: CZI, EMBO, ERC, FCT, H2021, H2022, InnOValley and Wellcome Trust News: Photonics.com, The Science Times, Optics.org and Phys.org Blogs: Springer Nature Protocols and Methods Community DOI: 10.1038/s41592-023-02057-w |
|
|
CLEM-Reg - An automated point cloud based registration algorithm for correlative light and volume electron microscopy Daniel Krentzel, Matouš Elphick, Marie-Charlotte Domart, Christopher J. Peddie, Romain F. Laine, Ricardo Henriques, Lucy M. Collinson, Martin L. Jones Preprint published in bioRxiv, May 2023 Technologies: CARE and ZeroCostDL4Mic Funded by: CZI and ERC DOI: 10.1101/2023.05.11.540445 |
|
|
Fast4DReg–fast registration of 4D microscopy datasets Joanna W Pylvänäinen, Romain F Laine, Bruno MS Saraiva, Sujan Ghimire, Gautier Follain, Ricardo Henriques, Guillaume Jacquemet Paper published in Journal of Cell Science, January 2023 Technologies: CARE, Fast4DReg, NanoJ and ZeroCostDL4Mic Funded by: CZI and ERC DOI: 10.1242/jcs.260728 |
|
|
DeepBacs for multi-task bacterial image analysis using open-source deep learning approaches Christoph Spahn, Estibaliz Gómez-de-Mariscal, Romain F. Laine, Pedro M. Pereira, Lucas von Chamier, Mia Conduit, Mariana G. Pinho, Guillaume Jacquemet, Séamus Holden, Mike Heilemann, Ricardo Henriques Paper published in Communications Biology, July 2022 Technologies: BioImage Model Zoo, CARE, DeepBacs, NanoJ, NanoJ-SQUIRREL, NanoJ-SRRF and ZeroCostDL4Mic Funded by: CZI, ERC and Wellcome Trust DOI: 10.1038/s42003-022-03634-z |
|
|
Democratising deep learning for microscopy with ZeroCostDL4Mic Lucas von Chamier, Romain F. Laine, Johanna Jukkala, Christoph Spahn, Daniel Krentzel, Elias Nehme, Martina Lerche, Sara Hernández-Pérez, Pieta K. Mattila, Eleni Karinou, Séamus Holden, Ahmet Can Solak, Alexander Krull, Tim-Oliver Buchholz, Martin L. Jones, Loïc A. Royer, Christophe Leterrier, Yoav Shechtman, Florian Jug, Mike Heilemann, Guillaume Jacquemet, Ricardo Henriques Paper published in Nature Communications, April 2021 Technologies: CARE, FBSR-TFM, NanoJ, NanoJ-SQUIRREL, NanoJ-SRRF and ZeroCostDL4Mic Funded by: EMBO, ERC and Wellcome Trust News: AZO Life Sciences, Drug Target Review, Nanotechnology Now and The Medical News Blogs: Microbiome Digest - Bik's Picks DOI: 10.1038/s41467-021-22518-0 |
|
|
Application of Super-Resolution and Advanced Quantitative Microscopy to the Spatio-Temporal Analysis of Influenza Virus Replication Emma Touizer, Christian Sieben, Ricardo Henriques, Mark Marsh, Romain F. Laine Review published in Viruses, February 2021 Technologies: NanoJ-VirusMapper, Super-Beacons and ZeroCostDL4Mic Funded by: Wellcome Trust DOI: 10.3390/v13020233 |
|
|
Single-Molecule Super-Resolution Imaging of T-Cell Plasma Membrane CD4 Redistribution upon HIV-1 Binding Yue Yuan, Caron A. Jacobs, Isabel Llorente Garcia, Pedro M. Pereira, Scott P. Lawrence, Romain F. Laine, Mark Marsh, Ricardo Henriques Paper published in Viruses, January 2021 Technologies: CARE Funded by: ERC DOI: 10.3390/v13010142 |
|
|
Avoiding a replication crisis in deep-learning-based bioimage analysis Romain F Laine, Ignacio Arganda-Carreras, Ricardo Henriques, Guillaume Jacquemet Perspective published in Nature methods, January 2021 Technologies: CARE and ZeroCostDL4Mic Funded by: EMBO, ERC and Wellcome Trust DOI: 10.1038/s41592-021-01284-3 |
|
|
An Introduction to Live-Cell Super-Resolution Imaging Siân Culley, Pedro Matos Pereira, Romain F Laine, Ricardo Henriques Book chapter published in Imaging from Cells to Animals In Vivo, January 2020 Technologies: CARE, NanoJ, NanoJ-Fluidics, NanoJ-SQUIRREL, NanoJ-SRRF and QuickPALM DOI: 10.1201/9781315174662-4 |
|
|
Fluctuation-based super-resolution traction force microscopy Aki Stubb, Romain F Laine, Mitro Miihkinen, Hellyeh Hamidi, Camilo Guzmán, Ricardo Henriques, Guillaume Jacquemet, Johanna Ivaska Paper published in Nano letters, January 2020 Technologies: CARE, FBSR-TFM, NanoJ, NanoJ-SQUIRREL and NanoJ-SRRF Funded by: BBSRC DOI: 10.1021/acs.nanolett.9b04083 |
|
|
Artificial intelligence for microscopy - what you should know Lucas von Chamier, Romain F. Laine, Ricardo Henriques Review published in Biochemical Society Transactions, July 2019 Technologies: CARE, NanoJ, NanoJ-Fluidics, NanoJ-SQUIRREL and NanoJ-SRRF Funded by: BBSRC and Wellcome Trust DOI: 10.1042/bst20180391 |
|
|
Automating multimodal microscopy with NanoJ-Fluidics Pedro Almada, Pedro M. Pereira, Siân Culley, Ghislaine Caillol, Fanny Boroni-Rueda, Christina L. Dix, Guillaume Charras, Buzz Baum, Romain F. Laine, Christophe Leterrier, Ricardo Henriques Paper published in Nature Communications, March 2019 Technologies: NanoJ, NanoJ-Fluidics, NanoJ-SQUIRREL, NanoJ-SRRF and NanoJ-VirusMapper Funded by: BBSRC and Wellcome Trust News: Technology Times, MSN, DNYUZ and Express Informer DOI: 10.1038/s41467-019-09231-9 |
|
|
NanoJ - a high-performance open-source super-resolution microscopy toolbox Romain F Laine, Kalina L Tosheva, Nils Gustafsson, Robert D M Gray, Pedro Almada, David Albrecht, Gabriel T Risa, Fredrik Hurtig, Ann-Christin Lindås, Buzz Baum, Jason Mercer, Christophe Leterrier, Pedro M Pereira, Siân Culley, Ricardo Henriques Paper published in Journal of Physics D - Applied Physics, January 2019 Technologies: NanoJ, NanoJ-Fluidics, NanoJ-SQUIRREL, NanoJ-SRRF, NanoJ-VirusMapper and QuickPALM Funded by: BBSRC and Wellcome Trust DOI: 10.1088/1361-6463/ab0261 |
|
Funding with our group
|
Beyond protein localization - monitoring molecular function with nanometer sensitivity Ricardo Henriques, Romain Laine, Takeharu Nagai, Kai Lu Funded by: UCL - Strategic Partner Fund - Establishing collaborative research between UCL and Osaka University Duration: September 2019 - August 2020 |
|
|
Establishing collaborative research between UCL and Institut Curie Ricardo Henriques, Romain Laine, Bassam Hajj Funded by: UCL - Cities Partnership Programme Duration: June 2019 - June 2019 |
