Research Team


Romain F. Laine

Romain F. Laine

Postdoc


Started in: December 2017

Ended in: September 2020

Funding: BBSRC Grant; MRC Fellowship


Romain was a 3-year Postdoc in our research group. Worked on 13 publications. Contributed to 8 technologies. Raised 3 grants. Collaborated with 15 labs. Mentored 1 Masters Student, 1 Internship Student, 2 PhD Students.

In the news


Supervisees

Cheng-Yu Huang

Cheng-Yu Huang

Masters Student
Alumni

Daniel Krentzel

Daniel Krentzel

Internship Student
Crick Sandwich Student

Lucas von Chamier

Lucas von Chamier

PhD Student
MRC-LMCB Studentship

Yue Yuan

Yue Yuan

PhD Student
Alumni


Collaborations

Bassam Hajj

Bassam Hajj

Institut Curie
Paris, France

Joint: 1 1

Buzz Baum

Buzz Baum

MRC-LMB
Cambridge, UK

Joint: 6 3 1

Caron Jacobs

Caron Jacobs

University of Cape Town
Cape Town, South Africa

Joint: 3 2

Christophe Leterrier

Christophe Leterrier

Aix Marseille Université, CNRS, INP
Marseille, France

Joint: 10

Florian Jug

Florian Jug

Human Technopole
Milan, Italy

Joint: 3 1

Guillaume Jacquemet

Guillaume Jacquemet

Abo Akademi University
Turku, Finland

Joint: 16 1

Jason Mercer

Jason Mercer

University of Birmingham
Birmingham, UK

Joint: 6 4

Loïc Royer

Loïc Royer

Chan Zuckerberg Biohub
San Francisco, USA

Joint: 2

Lucy Collinson

Lucy Collinson

The Francis Crick Institute
London, UK

Joint: 1 1 2

Mariana Pinho

Mariana Pinho

ITQB NOVA
Oeiras, Portugal

Joint: 4 1 2

Mark Marsh

Mark Marsh

UCL
London, UK

Joint: 4 2

Mike Heilemann

Mike Heilemann

Goethe University
Frankfurt, Germany

Joint: 3 1

Pedro Matos Pereira

Pedro Matos Pereira

ITQB NOVA
Oeiras, Portugal

Joint: 20 3

Séamus Holden

Séamus Holden

Warwick University
Warwick, UK

Joint: 5

Yoav Shechtman

Yoav Shechtman

Technion - Israel Institute of Technology
Haifa, Israel

Joint: 4


Technologies

CLEM-Reg CLEM-Reg
DeepBacs DeepBacs
Fast4DReg Fast4DReg
FBSR-TFM FBSR-TFM
NanoJ-eSRRF NanoJ-eSRRF
NanoJ-Fluidics NanoJ-Fluidics
ZeroCostDL4Mic ZeroCostDL4Mic

Publications with our group (see more on Google Scholar)

High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation
Romain F. Laine, Hannah S. Heil, Simao Coelho, Jonathon Nixon-Abell, Angélique Jimenez, Theresa Wiesner, Damián Martínez, Tommaso Galgani, Louise Régnier, Aki Stubb, Gautier Follain, Samantha Webster, Jesse Goyette, Aurelien Dauphin, Audrey Salles, Siân Culley, Guillaume Jacquemet, Bassam Hajj, Christophe Leterrier, Ricardo Henriques
Paper published in Nature Methods, November 2023
Technologies: CARE, NanoJ, NanoJ-eSRRF, NanoJ-SQUIRREL, NanoJ-SRRF, NanoPyx and Nuclear-Pores as references
Funded by: CZI, EMBO, ERC, FCT, H2021, H2022, InnOValley and Wellcome Trust
News: Photonics.com, The Science Times, Optics.org and Phys.org
Blogs: Springer Nature Protocols and Methods Community
DOI: 10.1038/s41592-023-02057-w
CLEM-Reg - An automated point cloud based registration algorithm for correlative light and volume electron microscopy
Daniel Krentzel, Matouš Elphick, Marie-Charlotte Domart, Christopher J. Peddie, Romain F. Laine, Ricardo Henriques, Lucy M. Collinson, Martin L. Jones
Preprint published in bioRxiv, May 2023
Technologies: CARE and ZeroCostDL4Mic
Funded by: CZI and ERC
DOI: 10.1101/2023.05.11.540445
Fast4DReg–fast registration of 4D microscopy datasets
Joanna W Pylvänäinen, Romain F Laine, Bruno MS Saraiva, Sujan Ghimire, Gautier Follain, Ricardo Henriques, Guillaume Jacquemet
Paper published in Journal of Cell Science, January 2023
Technologies: CARE, Fast4DReg, NanoJ and ZeroCostDL4Mic
Funded by: CZI and ERC
DOI: 10.1242/jcs.260728
DeepBacs for multi-task bacterial image analysis using open-source deep learning approaches
Christoph Spahn, Estibaliz Gómez-de-Mariscal, Romain F. Laine, Pedro M. Pereira, Lucas von Chamier, Mia Conduit, Mariana G. Pinho, Guillaume Jacquemet, Séamus Holden, Mike Heilemann, Ricardo Henriques
Paper published in Communications Biology, July 2022
Technologies: BioImage Model Zoo, CARE, DeepBacs, NanoJ, NanoJ-SQUIRREL, NanoJ-SRRF and ZeroCostDL4Mic
Funded by: CZI, ERC, FCT and Wellcome Trust
DOI: 10.1038/s42003-022-03634-z
Democratising deep learning for microscopy with ZeroCostDL4Mic
Lucas von Chamier, Romain F. Laine, Johanna Jukkala, Christoph Spahn, Daniel Krentzel, Elias Nehme, Martina Lerche, Sara Hernández-Pérez, Pieta K. Mattila, Eleni Karinou, Séamus Holden, Ahmet Can Solak, Alexander Krull, Tim-Oliver Buchholz, Martin L. Jones, Loïc A. Royer, Christophe Leterrier, Yoav Shechtman, Florian Jug, Mike Heilemann, Guillaume Jacquemet, Ricardo Henriques
Paper published in Nature Communications, April 2021
Technologies: CARE, FBSR-TFM, NanoJ, NanoJ-SQUIRREL, NanoJ-SRRF and ZeroCostDL4Mic
Funded by: EMBO, ERC and Wellcome Trust
News: AZO Life Sciences, Drug Target Review, Nanotechnology Now and The Medical News
Blogs: Microbiome Digest - Bik's Picks
DOI: 10.1038/s41467-021-22518-0
Application of Super-Resolution and Advanced Quantitative Microscopy to the Spatio-Temporal Analysis of Influenza Virus Replication
Emma Touizer, Christian Sieben, Ricardo Henriques, Mark Marsh, Romain F. Laine
Review published in Viruses, February 2021
Technologies: NanoJ-VirusMapper, Super-Beacons and ZeroCostDL4Mic
Funded by: Wellcome Trust
DOI: 10.3390/v13020233
Single-Molecule Super-Resolution Imaging of T-Cell Plasma Membrane CD4 Redistribution upon HIV-1 Binding
Yue Yuan, Caron A. Jacobs, Isabel Llorente Garcia, Pedro M. Pereira, Scott P. Lawrence, Romain F. Laine, Mark Marsh, Ricardo Henriques
Paper published in Viruses, January 2021
Technologies: CARE
Funded by: ERC
DOI: 10.3390/v13010142
Avoiding a replication crisis in deep-learning-based bioimage analysis
Romain F Laine, Ignacio Arganda-Carreras, Ricardo Henriques, Guillaume Jacquemet
Perspective published in Nature methods, January 2021
Technologies: CARE and ZeroCostDL4Mic
Funded by: EMBO, ERC and Wellcome Trust
DOI: 10.1038/s41592-021-01284-3
An Introduction to Live-Cell Super-Resolution Imaging
Siân Culley, Pedro Matos Pereira, Romain F Laine, Ricardo Henriques
Book chapter published in Imaging from Cells to Animals In Vivo, January 2020
Technologies: CARE, NanoJ, NanoJ-Fluidics, NanoJ-SQUIRREL, NanoJ-SRRF and QuickPALM
DOI: 10.1201/9781315174662-4
Fluctuation-based super-resolution traction force microscopy
Aki Stubb, Romain F Laine, Mitro Miihkinen, Hellyeh Hamidi, Camilo Guzmán, Ricardo Henriques, Guillaume Jacquemet, Johanna Ivaska
Paper published in Nano letters, January 2020
Technologies: CARE, FBSR-TFM, NanoJ, NanoJ-SQUIRREL and NanoJ-SRRF
Funded by: BBSRC
DOI: 10.1021/acs.nanolett.9b04083
Artificial intelligence for microscopy - what you should know
Lucas von Chamier, Romain F. Laine, Ricardo Henriques
Review published in Biochemical Society Transactions, July 2019
Technologies: CARE, NanoJ, NanoJ-Fluidics, NanoJ-SQUIRREL and NanoJ-SRRF
Funded by: BBSRC and Wellcome Trust
DOI: 10.1042/bst20180391
Automating multimodal microscopy with NanoJ-Fluidics
Pedro Almada, Pedro M. Pereira, Siân Culley, Ghislaine Caillol, Fanny Boroni-Rueda, Christina L. Dix, Guillaume Charras, Buzz Baum, Romain F. Laine, Christophe Leterrier, Ricardo Henriques
Paper published in Nature Communications, March 2019
Technologies: NanoJ, NanoJ-Fluidics, NanoJ-SQUIRREL, NanoJ-SRRF and NanoJ-VirusMapper
Funded by: BBSRC and Wellcome Trust
News: Technology Times, MSN, DNYUZ and Express Informer
DOI: 10.1038/s41467-019-09231-9
NanoJ - a high-performance open-source super-resolution microscopy toolbox
Romain F Laine, Kalina L Tosheva, Nils Gustafsson, Robert D M Gray, Pedro Almada, David Albrecht, Gabriel T Risa, Fredrik Hurtig, Ann-Christin Lindås, Buzz Baum, Jason Mercer, Christophe Leterrier, Pedro M Pereira, Siân Culley, Ricardo Henriques
Paper published in Journal of Physics D - Applied Physics, January 2019
Technologies: NanoJ, NanoJ-Fluidics, NanoJ-SQUIRREL, NanoJ-SRRF, NanoJ-VirusMapper and QuickPALM
Funded by: BBSRC and Wellcome Trust
DOI: 10.1088/1361-6463/ab0261

Funding with our group

Beyond protein localization - monitoring molecular function with nanometer sensitivity
Ricardo Henriques, Romain Laine, Takeharu Nagai, Kai Lu
Funded by: UCL - Strategic Partner Fund - Establishing collaborative research between UCL and Osaka University
Duration: September 2019 - August 2020
Establishing collaborative research between UCL and Institut Curie
Ricardo Henriques, Romain Laine, Bassam Hajj
Funded by: UCL - Cities Partnership Programme
Duration: June 2019 - June 2019
Applying advanced microscopy techniques to decipher functional and structural organisation of life at multiple scale
Romain Laine
Funded by: MRC - Skills Development Research Fellow
Duration: April 2019 - March 2021