Enabling Live-Cell 4D Super-Resolution Microscopy Guided by Artificial Intelligence

Alias: SelfDriving4DSR
Agency: ERC
Type: Consolidator
Principal Investigator: Ricardo Henriques
Start-date: Julho 2021
End-date: Junho 2026
DOI: 10.3030/101001332

Project aims to develop a "self-driving" 4D super-resolution microscope guided by AI for long-term live cell imaging with nanoscale resolution. It will use computational optics, machine learning, and adaptive optics to optimize imaging conditions based on the biological sample. A pilot study will track HIV viral infection in cells for over 24 hours to gain new insights into virus latency and replication efficiency linked to entry events previously unobservable.